First off, a few comics you might want to take a look at: Nothing Better, by Tyler Page; and Goblins, by Tarol Hunt. These are both one-page-a-week comics, so they don't fit the TWIW paradigm exactly. A college comic, Nothing Better(1) tackles college life, and is currently wrapping up a nightmare sequence where an angry God confronts avowed Atheist Kat of the cast - and Goblins(2) has been in the throes of a confrontation between our heroes and an entire town of guardsmen and goblin killers for quite some time. Head to the main page of Nothing Better and hit the back button once to see all of the current issue up to this point all at once; for Goblins, I wouldn't start reading any earlier than the third book heading in the archives, or maybe even from the beginning :/
Several prominent webcomics have wrapped up some heavy stories this week: I am thinking of Sam and Fuzzy(3), Dr. McNinja(4) and Penny and Aggie(5), to be specific. Sam and Fuzzy just completed a storyline that was years of regular updates long, a feat rarely seen, and of course this means that new is the perfect time to catch up on this wonderful comic. Head to the Noosehead storyline and see for yourself how well all the pieces have been put together - http://www.samandfuzzy.com, people.
Dr. McNinja's plotline completed just today; the Doctor's final thoughts are available for perusal, and we, the readers, can puzzle for ourselves over what the future place of King Rad in the comic universe may end up being. I, for one, am hoping that there will be a bit more pseudo-medical expertise involved in his next caper - not that I'm complaining overly about the extreme antics of his ex-college buddy during the fight scenes in this chapter overmuch.
Penny and Aggie, an old time favorite of mine, is beginning to step into particularly difficult subject matter for me to grasp - girls being awful to girls, terrible cliques plotting school domination, and the like - but the emotional impact in the final pages of the story closing out this week was completely arresting. I won't say that it's undeniably entertaining or anything so ambitious, but I will say that for those of us who have been following the comic from the beginning and wondering what kind of a friend Penny is really, this was a real eye opener.
One more piece of comic recommendation for you folks: Princess Planet (6). I don't know if you'll all like it, but I do know if you read the most recent update and love it then you should start scouring the archives immediately.